Stem cells in the Drosophila intestine
Allison Bardin’s team studies regulatory mechanisms controlling adult stem cells. Using genetic and genomic approaches, they aim to:
(1) identify mechanisms regulating stem cell self-renewal, and
(2) determine how aging and environmental insults impact this process through alteration of the stem cell genome.
Understanding the dual capacity of self-renewal and differentiation is an important aim of regenerative medicine and also has implications for cancer biology. The aim of work in our group is to identify mechanisms important for these processes and ultimately to understand how they function collectively to promote homeostasis of a tissue.
We are using a simplified model system, the Drosophila intestine, which contains around 1000 multipotent intestinal stem cells. The intestinal stem cells produce the two differentiated cell types required for organ function: the enterocytes and enteroendocrine cells. The differentiated cells are replaced approximately once a week in healthy animals but can be stimulated to rapidly regenerate the intestine upon infection by pathogenic bacteria or treatment with damaging agents). Thus, this is an excellent and simple model for mammalian tissues such as the intestine, lung or skin that need to regenerate in response to environmental stimuli. We are using this model system to address two important questions:
1. How is the proliferation of stem cells regulated?
2. How does DNA damage impact stem cells and tissues during aging?
Our work has implications for understanding how adult tissues function and how they become deregulated during aging and cancer.
• 2003: PhD, Massachusetts Institute of Technology, Boston, USA, Angelika Amon’s lab
• 2003-2006: Postdoc, Ecole Normale Supérieure, Paris, France. François Schweisguth’s lab
• 2006-2010: 1st permanent position, Institut Pasteur, Paris, France. François Schweisguth’s lab
• 2010: 1st group leader position. Appointed Group Leader at the Institut Curie, Paris, France.
• Bronze Medal of the CNRS (Best Young Researchers), 2016
• Laureate of the ATIP-Avenir Plus Program, CNRS-Inserm, 2014
• Laureate of the ATIP-Avenir Program, 2011
Juillet 2016, article de l’Institut Curie
Apr 2015, Worldwide Cancer Research video
Oct 2017, Curr Opin Cell Biol
Jul 2017, EMBO J
Apr 2017, Fly (Austin)
Nov 2015, Nat Commun