cavalli portrait

Giacomo Cavalli

Current position

Group leader, Research Director (CNRS)

Host institution

Institute of Human Genetics, Montpellier, CNRS, France

Epigenetics and developmental regulation


Giacomo Cavalli is investigating heredity and gene regulation laws beyond DNA sequence. He and his lab discovered that the 3D structure of chromosomes can be heritable and that it contributes to genome regulation. Furthermore, they provided the first high-resolution description of the principles of genome folding in animals. Finally, the Cavalli lab showed that PcG proteins regulate cell proliferation and have tumor suppression activity in flies, a model system which harbors 75% of the genes known to cause a disease in humans.

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• 1994, PhD in Natural Sciences, ETH Zürich, Switzerland. Fritz Thomas’ lab, chromatin and transcription in yeast.

• 1995-1998 Postdoc at the University of Heidelberg, Germany. Renato Paro’s Lab, Polycomb proteins and fly development


• Honour team, Fondation Association pour la Recherche sur le Cancer, 2013

• Allianz Foundation Research Prize, 2012

• Silver Medal of the CNRS, 2011

• Award of a grant for the Laboratory of Excellence EpiGenMed, 2011

• Advanced Investigator Grant of the European Research Council (ERC), 2008