Guillaume Canaud

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Guillaume, Canaud

Current position

Professeur de Université-Praticien Hospitalier (PU-PH)

Host Institution

Université de Paris, Institut Necker-Enfants Malades (U1151), Hôpital Necker-Enfants Malades

Molecular mechanisms underlying PIK3CA-related overgrowth syndromes

Our group is dedicated to decipher the mechanisms underlying the physiopathology of overgrowth syndromes in order to improve patient’s condition. We have been working since a long time on the PIK3/AKT/mTOR pathway in the context of kidney diseases but based on a patient experience, we have progressively moved to this new field in 2016. We are trying to decipher the molecular mechanisms underlying overgrowth syndromes. To this aim, we combine complementary in vivo and in vitro approaches, experimental models of overgrowth on genetically modified mice, as well as the use of very innovative and new technology of bioengineering. The support of the FSER will be essential to achieve our goal.



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• 1995: High School Graduation (Mathematics and Biological Sciences)
• 1997: Master degree in biological and medical sciences
• 1996 – 2002: Medical studies, Montpellier University I, France
• 1998: Degree of Anatomy and Organogenesis, Montpellier University
• 1999: Degree of Neuroanatomy, Montpellier University I, France
• 2002 – 2007: Resident in Nephrology
• 2004: Degree of Intensive Care Medicine, Paris-University XI, France
• 2005: Postgraduate degree in Immunology, U764, Paris-University XI,
• 2007: Dissertation for the requirement of MD degree. Thesis « Recurrent FSGS after kidney transplantation», Paris Descartes University, France
• 2007: Medical board certification (Nephrology)
• 2007 – 2012: Senior Resident in Nephrology and Transplantation (Prof. Legendre), Necker Hospital, Paris Descartes University, France
• 2008 – 2012: PhD in Dr. Fabiola Terzi Laboratory (Molecular and Cellular biology), INSERM U1151, Necker Hospital, Paris. 10/10/2012 PhD defense: ‘AKT/mTORC pathway in chronic kidney disease progression’
• 2012 – 2014: Postdoctoral fellowship in Prof. Joseph Bonventre Laboratory (‘Kidney Injury and Repair’), Brigham and Women's Hospital, Harvard Medical School, Boston, USA
• 2014 – 2019: Associate Professor of Medicine, Renal Division, Necker Hospital, Paris Descartes University, France
• 2018: Head of the laboratory (U1151-Team Canaud)
• Sept 2019: Full Professor of Medicine, Necker Hospital, Paris Descartes University, France


• 2010 Young Investigator Award of the Necker Research Center (INEM)
• 2014 Young Investigator Award of the Bettencourt-Schueller Foundation
• 2014 Young Investigator Award of the Phillip Foundation
• 2014 Young Investigator Award of the Foundation for Science, Servier
• 2014 Young Investigator Award of the French Society of Nephrology
• 2015: European Research Council (ERC) starting grant (N° 679254)
• 2016: ERC Proof of Concept (N°737546)
• 2017 Basic Science Young Investigator Award of “Fondation Tourre”
• 2018 Basic Science Young Investigator Award of “Fondation Cino Del Duca”
• 2018 Grand Prix Jean Lecocq, French Academy of Science
• 2019 Grand Prix Jean Hamburger de la Ville de Paris
• 2019 Grand Prix de l’Association Robert Debré pour la Recherche Médicale
• 2019 1st Prize Line Renaud-Loulou Gasté
• 2019 Prize Eloi Collery French Academy of Medicine
• 2019 Prix cercle FSER
• 2019 RHU (French Gouvernemental grant, Investissement d’Avenir, 9.5M€)
• 2020 Prix Jean Valade, Fondation de France