Jean-Antoine Girault aims to identify the intracellular signalization mechanisms which underlie long term behavioral changes. The ability of the nervous system to adapt to a variable environment indeed depends on the modulation and plasticity of synapses between these neurons, which is regulated by their activity and by multiple neuromodulators.
Long term changes also involve morphological modifications and variations in the translation of proteins and transcription of genes.
Current research in the lab includes genome-wide studies of cell type-specific transcription and epigenetic modifications in basal ganglia, as well as exploration of the role of tyrosine kinase Pyk2 in neuronal properties and neurodegenerative diseases.
• 1984 MD., University Paris 6, France
• 1986 Ph.D. in Health and Life sciences, Molecular and Cellular Pharmacology, University Paris 6, France, Marie-Jo Besson’s lab
• 1987 Postdoctoral fellow, Rockfeller University, New-York, USA, Paul Greengard’s lab
• 1990 Appointed Group Leader at the Collège de France and Research Scientist (CR1) at Inserm, Paris, France
• Brixham Foundation Price, attributed by the Foundation for Medical Research, 2016
• Lamonica Award for Neurobiology, French Academy of Sciences, 2013
• European Research Council (ERC) Advanced Grant 2010
• Coup d’élan Grant, Foundation Bettencourt-Schueller, 2002
• Antoine Lacassagne Award, French Academy of Sciences, 1997
• Stanley Award, National Alliance for the Mentally Ill, 1990
Interview in Le Figaro Où se trouve le siège de la mémoire ?
Brain’s week 2017
Interview in Santé Magasine A quoi sert la dopamine ?
Brain’s week 2016
Feb 2015, Nat Commun.
June 2013, Proc. Natl. Acad. Sci. USA