Mario Pende

Current position

Group leader, Research Director (DR1)

Host institution

Necker Institute for Sick Children, Paris, Inserm, France

Pancreatic islet cells displaying TOR activation (brown staining) have a growth advantage

Cell growth control by nutrients


Food intake may dictate metabolic adaptations as well as the control of cell growth and proliferation. Mario Pende’s goal is to better understand the coordination of these responses. He and his team are stuyding the protein kinase Target Of Rapamycin (TOR) which has an evolutionary conserved role in the integration of nutritional cues. The pathophysiological impact of TOR activity will be analyzed in growth and metabolic diseases in mammals.

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• 2000 Ph. D. in Biochemistry, Friedrich Miescher Institute, University of Basel, Switzerland. George Thomas’ lab

• 2001 Appointed Group Leader at the Necker Institute, Paris, France


• Visiting professor, Nankai University, Tianjin, China, 2016

• Henri LABBÉ Prize (Integrative Biology), French Academy of Sciences, 2014

• Consolidator Grant, European Research Council (ERC), 2013

• Starting Grant, European Research Council (ERC), 2008

• G. B. Morgagni Silver medal Young Investigator Award, Servier, 2006

• Avenir Inserm Award, 2002