2022. Jonathan Elegheert and his team investigate how neuronal cells in the brain make contacts and communicate with each other. They study the molecular structures and interaction determinants of synaptic protein complexes involved in neurodevelopmental disorders and neuronal disease....
2022. Rebekka Wild and her research group are investigating the enzymes involved in glycosaminoglycan biosynthesis on an atomic level. Glycosaminoglycans are long and complex sugar chains found on the cell surface of all animal cells, ranging from sea anemone to humans, and they play an important role in diverse biological...
2019. Francesca Giordano and her team work to figure out the role of membrane contact sites or nearby membrane attachment sites (at 10-30nm) in the transport of lipids between endoplasmic reticulum and other intracellular organelles. The exchange of non-vesicular lipids at membrane contact sites emerges as one of the key...
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Bernardo Reina San Martin is interested in the molecular mechanisms driving the diversification of the repertoire of B-cells, the cells of our immune system producing antibodies. He specifically investigates somatic hypermutation (SHM) and class switch recombination (CSR), two processes involved in the immune response to generate an antibody mediated answer,...
Alternative splicing is a process allowing cells to make different products from one gene. Since it was discovered over three decades ago now, it has been shown that it has key roles especially in tissue differentiation and pathologies like hereditary diseases and cancer. Frédéric Allain is determining with his team the...
Food intake may dictate metabolic adaptations as well as the control of cell growth and proliferation. Mario Pende's goal is to better understand the coordination of these responses. He and his team are stuyding the protein kinase Target Of Rapamycin (TOR) which has an evolutionary conserved role in the integration...