2022. Ines Drinnenberg and her research group are investigating the evolutionary diversity of centromeres, regions on eukaryotic chromosomes, which are essential for cell division. Despite their important role, centromeres are highly diverse across species. Using evolution-guided approaches the group studies the architecture and regulation of unconventional centromeric...
2021. Céline Vallot and her research group are investigating epigenetic mechanisms driving tumor plasticity. These study how chemical modifications of the chromatin, structuring DNA, play a role in defining the phenotype of cancer cells. They explore the dynamics of acquisition of epigenetic features in cancer cells, to understand how these...
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Research in Maria-Elena Torres-Padilla’s laboratory focuses on understanding how early mouse development is regulated by chromatin-mediated changes in gene regulation, that is, by epigenetic information. In particular, we are interested in understanding how the transitions in cell potency and cell fate are regulated by chromatin-mediated processes. ...
The overall objective of Manolis Papamichos-Chronakis group is to decipher the interplay between the multiple machineries that keep our genome intact and the chromatin structure of DNA. Using a combination of genetics, cell imaging and high-throughput technologies in budding yeast and human cells they are exploring the role of chromatin...
Research in Maria-Elena Torres-Padilla’s laboratory focuses on understanding how early mouse development is regulated by chromatin-mediated changes in gene regulation, that is, by epigenetic information. In particular, we are interested in understanding how the transitions in cell potency and cell fate are regulated by chromatin-mediated processes. ...
We each have two versions or alleles of each gene, one from our father, one from our mother. Parental genomic imprinting is an epigenetic mechanism that restrains the expression of an allele depending on its origin, paternal or maternal. The alteration of this process at defined loci results in different...