2021. Céline Vallot and her research group are investigating epigenetic mechanisms driving tumor plasticity. These study how chemical modifications of the chromatin, structuring DNA, play a role in defining the phenotype of cancer cells. They explore the dynamics of acquisition of epigenetic features in cancer cells, to understand how these...
2020. The main focus of our research is understanding how adult stem cells are maintained throughout life, how they generate and regenerate tissues and how they relate to tumor development. We focus on studying how the Notch signalling pathway controls cell fate specification and lineage segregation, in coordination with tissue...
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Christian Braendle is interested in understanding how environmental variation and genotype-environment interactions contribute to phenotypic variation. He is using the C. elegans model as well as closely related species to study how environmental variation modulates developmental processes and their phenotypic outcomes, including fitness consequences. ...
The overall objective of Manolis Papamichos-Chronakis group is to decipher the interplay between the multiple machineries that keep our genome intact and the chromatin structure of DNA. Using a combination of genetics, cell imaging and high-throughput technologies in budding yeast and human cells they are exploring the role of chromatin...
We each have two versions or alleles of each gene, one from our father, one from our mother. Parental genomic imprinting is an epigenetic mechanism that restrains the expression of an allele depending on its origin, paternal or maternal. The alteration of this process at defined loci results in different...
Animal’s morphological and behavioral traits are specified by genes during embryological development. Those traits change through species evolution via genetic modifications which are affecting developmental processes. Benjamin Prud’homme’s aim is to identify those genetic changes and to understand how they translate into morphological of behavioral modifications....
X-inactivation is a process by which one of the two X chromosomes is transcriptionally silenced during early development in female mammals. It allows for dosage compensation between XX females and XY males. Edith Heard is studying this paradigm for developmental epigenetics to gain insights into the fundamental mechanisms that underlie...