Gérard Eberl is investigating immunity mecanisms. Pro-inflammatory cells, stromal cells and microbiota all interact to define health and immunity of the host, and its interaction with the environment. Using mouse models, Gérard Eberl and his team aim at defining the mechanisms by which these equilibria are maintained during health and...
Robert Menard is investigating how the malaria parasite develops in the skin and the liver before reaching the red blood cells (the pre-rythrocytic phase). His goal with his team is to identify parasite products important for the key steps of the infection and to decipher protection mechanisms in that phase,...
Jost Enninga establishes novel tools that yield information on the molecular details of bacterial pathogen infection in the context of single living cells with unprecedented spatiotemporal resolution....
Nicolas Manel and his research group are studying the principles and mechanisms of innate immunity in humans and its impact on adaptive immunity using HIV and other models....
Bruno Lemaitre and his research group are investigating mechanisms regulating the interactions between animals and microorganisms. They study both microbial infections (the host defense responses to a pathogenic situation), and symbiotic situations (when the interaction is mutually beneficial for the fly and the bacteria). They also explore what makes...
Nathalie Vergnolle identifies and characterizes mediators of inflammation and pain in intestinal pathologies (Irritable Bowel Syndrome (IBS), Infectious Colitis, Inflammatory Bowel Diseases (IBD), and Inflammation-Associated Colorectal Cancers)....
In paradigm‐ shifting discoveries reported over two decades, Jean‐ Laurent Casanova has uncovered that life-threatening infectious diseases striking otherwise healthy children may be caused by single‐ gene inborn errors of immunity. Pursuing both biological and medical goals, he attempts to establish a genetic theory of childhood infectious diseases....