Guillaume Canaud

Guillaume, Canaud

2020 Laureate

Current position

Professeur de Université-Praticien Hospitalier (PU-PH)

Host Institution

Université de Paris, Institut Necker-Enfants Malades (U1151), Hôpital Necker-Enfants Malades

http://canaudlab.recherche.parisdescartes.fr

Guillaume.canaud@inserm.fr

An example of a senescent keratinocyte, displaying characteristic features including large flat appearance, multiple nuclei and vesicles, and enzymatic “Senescence-associated beta galactosidase” (SA-beta-gal) activity that stains the cell blue.

Mixed lymphatic and venous malformation developed by PIK3CACAGG-CreER mouse model (Venot Q et al, Nature 2018)

Molecular mechanisms underlying PIK3CA-related overgrowth syndromes

Our group is dedicated to deciphering the mechanisms underlying the pathophysiology of overgrowth syndromes and vascular abnormalities of genetic origin in order to propose new therapies to patients. We have been working for a long time on the PIK3/AKT/mTOR pathway in the context of renal diseases and have progressively shifted to vascular and hypergrowth pathologies. To decipher the molecular mechanisms underlying overgrowth syndromes, we combine complementary in vivo and in vitro approaches. We have created a large number of genetically modified mouse lines that recapitulate the syndromes presented by the patients. The strength of our team comes from the very high complementarity with the clinic, since I follow on a daily basis a unique cohort of more than 2000 patients with these pathologies. This complementarity allows us to refine the experimental models and to better understand the patients’ expectations.

Training

• 1995: High School Graduation (Mathematics and Biological Sciences)
• 1997: Master degree in biological and medical sciences
• 1996 – 2002: Medical studies, Montpellier University I, France
• 1998: Degree of Anatomy and Organogenesis, Montpellier University
• 1999: Degree of Neuroanatomy, Montpellier University I, France
• 2002 – 2007: Resident in Nephrology
• 2004: Degree of Intensive Care Medicine, Paris-University XI, France
• 2005: Postgraduate degree in Immunology, U764, Paris-University XI,
• 2007: Dissertation for the requirement of MD degree. Thesis « Recurrent FSGS after kidney transplantation», Paris Descartes University, France
• 2007: Medical board certification (Nephrology)
• 2007 – 2012: Senior Resident in Nephrology and Transplantation (Prof. Legendre), Necker Hospital, Paris Descartes University, France
• 2008 – 2012: PhD in Dr. Fabiola Terzi Laboratory (Molecular and Cellular biology), INSERM U1151, Necker Hospital, Paris. 10/10/2012 PhD defense: ‘AKT/mTORC pathway in chronic kidney disease progression’
• 2012 – 2014: Postdoctoral fellowship in Prof. Joseph Bonventre Laboratory (‘Kidney Injury and Repair’), Brigham and Women's Hospital, Harvard Medical School, Boston, USA
• 2014 – 2019: Associate Professor of Medicine, Renal Division, Necker Hospital, Paris Descartes University, France
• 2018: Head of the laboratory (U1151-Team Canaud)
• Sept 2019: Full Professor of Medicine, Necker Hospital, Paris Descartes University, France
• 2020 Consolidation Grant from the European Research Council (ERC) within the framework of the European Union's Horizon 2020 research and innovation programme
• Triennial and international Gagna A. & Ch. Van Heck Prize for incurable diseases (Belgian National Fund for Scientific Research)

Awards

• 2010 Young Investigator Award of the Necker Research Center (INEM)
• 2014 Young Investigator Award of the Bettencourt-Schueller Foundation
• 2014 Young Investigator Award of the Phillip Foundation
• 2014 Young Investigator Award of the Foundation for Science, Servier
• 2014 Young Investigator Award of the French Society of Nephrology
• 2015: European Research Council (ERC) starting grant (N° 679254)
• 2016: ERC Proof of Concept (N°737546)
• 2017 Basic Science Young Investigator Award of “Fondation Tourre”
• 2018 Basic Science Young Investigator Award of “Fondation Cino Del Duca”
• 2018 Grand Prix Jean Lecocq, French Academy of Science
• 2019 Grand Prix Jean Hamburger de la Ville de Paris
• 2019 Grand Prix de l’Association Robert Debré pour la Recherche Médicale
• 2019 1st Prize Line Renaud-Loulou Gasté
• 2019 Prize Eloi Collery French Academy of Medicine
• 2019 Prix cercle FSER
• 2019 RHU (French Gouvernemental grant, Investissement d’Avenir, 9.5M€)
• 2020 Prix Jean Valade, Fondation de France