2001 Laureate
Current position
Professor at the Rockfeller University, HHMI Investigator, Senior attending physician at the Rockfeller Hospital, Head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, Visiting Professor, Hôpital Necker
Host institution
The Rockfeller University, New York, The Howard Hughes Medical Institute USA, Necker Hospital for Sick Children, Paris, France
jean-laurent.casanova@rockfeller.edu
Herpes simplex encephalitis (HSE) is due to mutations in the TLR3-UNC93B1-IFN-α/β pathway with recent identification of mutations in TRIF and TBK1.
In paradigm‐ shifting discoveries reported over two decades, Jean‐ Laurent Casanova has uncovered that life-threatening infectious diseases striking otherwise healthy children may be caused by single‐ gene inborn errors of immunity. Pursuing both biological and medical goals, he attempts to establish a genetic theory of childhood infectious diseases.
•1987 : M.D. , University Paris 5 Descartes, France
•1992 : Ph. D. in Biology, University Paris 6 UPMC, Pasteur Institute and Ludwig Institute for Cancer Research, France & Switzerland, Janet Maryanski's lab
•1999 : Appointed Professor of Pediatrics, Necker Hospital, Paris, France
•1999 : Appointed Head of laboratory (with Laurent Abel), Necker Hospital, Paris, France
(Sélection)
•AAI-Steinman Award for Human Immunology Research, American Association of Immunologists (AAI), 2017
•"Grand prix" Inserm, 2016
•Robert Koch Prize, Germany, 2014
•HHMI Investigator Appointment, USA, 2013
•Ilse and Helmut Wachter Foundation Award, Innsbruck Medical University, Austria, 2012
•Seymour and Vivian Milstein Award, USA, 2012
•InBev-Baillet Latour Health Prize, Immunology and Infectious Diseases, Belgium, 2011
Jean-Laurent Casanova, le généticien qui repense les maladies infectieuses
Le Monde, Jan 2017
A human inborn error connects the α’s.
May 2016, Nat Immunol.
Pyogenic bacterial infections in humans with MyD88
Aug 2008, Science
TLR3 deficiency in patients with herpes simplex encephalitis Sep 2007, Science