Nathalie Vergnolle

Projects

The research focus of Nathalie Vergnolle’s INSERM team is focused on the study of four major intestinal pathologies: Irritable Bowel Syndrome (IBS), Infectious Colitis, Inflammatory Bowel Diseases (IBD), and Inflammation-Associated Colorectal Cancers.

Nathalie Vergnolle and her team aim at identifying and understanding the role and regulation of the mediators that are involved in inflammatory and pain mechanisms in the intestine during the course of those pathologies.

From this knowledge, they hope to identify new molecular targets that could be used for the treatment of those pathologies. Specifically, 4 major classes of molecules are studied: (1) the protease and their inhibitors, (2) the calcium channels of the transcient receptor potential (TRP) family, (3) the polyunsaturated fatty acid metabolites of the arachidonic cascade, and (4) the endogenous opioids of the enkephalin family.

Nathalie Vergnolle and her lab investigate the pathophysiology of the intestine as a whole, having developed both in vivo models of pathologies and in vitro models of cell cultures.

Impact

The specific objective of Nathalie Vergnolle’s lab is to improve our knowledge of the mechanisms responsible of inflammation and pain. Such knowledge of the mediators involved in chronic intestinal diseases would naturally highlight news pharmacological targets to cure these pathologies. Above all, the identified targets could also be considered for the treatment of chronic inflammatory diseases and pain in general.

Dernière mise à jour : 31 juillet 2014