2016 Laureate
Current position
Group leader
Host Institution
Institut Pasteur, Paris, France
pnavarro@pasteur.fr
Association of the studied transcription factor with chromatin during mitosis
Our body is constituted of more than 10 million trillion cells essentially containing the same genetic information; yet, they all are more or less different with no less than 300 clearly distinguishable cell types. The molecular mechanisms underlying the generation and preservation of such differences and cellular identities are based on the way our genes are controlled, allowing a single genome to be used in a multitude of different ways. These so-called epigenetic mechanisms are the focus of the investigations carried out in Pablo Navarro’s lab, where they use pluripotent cells derived from mouse embryos to explore the epigenetic mechanisms involved in the preservation of their outstanding potential. Indeed, during development pluripotent cells give rise to all the different cells of our body, a unique property that needs to be molecularly understood should we want to unfold their medical potential.
• 2006 PhD, Institut Pasteur, Paris, France, Claire Rougeulle (Philip Avner’s lab)
• 2006-2009: Postdoctoral fellow, Institut Pasteur, Paris, France, Phil Avner’s lab
• 2009-2013: Postodoctoral fellow, University of Edinburgh, Edinburgh, Scotland, United Kingdom, Ian Chamber’s lab
• 2013 Appointed Research associate (Institut Pasteur, permanent position)
• 2013 Appointed Group leader at the Institut Pasteur
• Marie-Curie IEF, 2010
• Newton award, The Royal Society, UK, 2009
• Medal of the french ‘Académie des Sciences’ , 2009
Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network.
Nov 2016, Nat Cell Biol
Molecular coupling of Tsix regulation and pluripotency
Nov 2010, Nature
Molecular coupling of Xist regulation and pluripotency
Sep 2008, Science