Patrick Delmas

Introduction

Patrick Delmas’ laboratory combines gene targeting, electrophysiology, histological methods and behavioral approaches to explore the channels, receptors and regulatory pathways that control sensory neuron functions.

Projects/Realizations

Genetic and physiological evidence from his lab suggests that Nav1.9 sodium channels are important players of the signaling mechanisms through which inflammatory mediators depolarize sensory neurons to produce pain hypersensitivity and neurogenic inflammation. Patrick Delmas and his team also study new mechanosensitive ion channels (K+ channels, TRPs, piezo channels) that detect gentle movement as well as noxious mechanical stimulation of the skin. They are working towards understanding the mechanism of activation of these channels under normal and pathological conditions, and aim at identifying additional sensory-specific ion channels. Patrick Delmas’ lab is building on these studies to extend our knowledge of the molecular processes that control neuronal sensory-transduction and electrogenesis. On a related front, they are developing potent and selective inhibitors for sensory ion channels as potential antalgic agents.

Impact

The long-term goal of the research conducted in Patrick Delmas’ lab is to synthesize an integrated picture of sensory neuron function. Their findings yield insights into the basic biology of the peripheral nervous system and have an impact on novel treatments for sensory diseases and pain.