Silvia Fre

Silvia Fre - Photo (b&w)

Silvia, Fre

Current position

Group Leader, Inserm Research Director (DR2)

Host Institution

Institut Curie

Coordination of celle fate specification and morphogenesis in mammals

The main focus of our research is understanding how adult stem cells are maintained throughout life, how they generate and regenerate tissues and how they relate to tumor development. We focus on studying how the Notch signalling pathway controls cell fate specification and lineage segregation, in coordination with tissue morphogenesis during development. Methodologically, we combine in vivo clonal analysis by lineage tracing in mice with time-lapse analysis of 3D organotypic cultures and intravital imaging, whole mount immunofluorescence, barcoding and transcriptomic analyses and mathematical modelling of clonal dynamics. Our studies have important implications for understanding cell plasticity in vivo and to clarify how reactivation of embryonic developmental programs in adult cells could lead to cancer.

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2006: PhD, Pierre and Marie Curie University, Paris, France

1999-2004: Post-doctoral Fellow, Harvard Medical School, Boston, US, Spyros Artavanis-Tsakonas’ lab

2005-2009: Post-doctoral Fellow, Department of Cell Biology, Institut Curie, Paris, France, Daniel Louvard’s lab

2010: Research scientist (Inserm CR1 permanent position), Department of Cell Biology, Institut Curie, Paris, France, Daniel Louvard’s lab

2013: Junior Group Leader, Department of Genetics and Developmental Biology, Institut Curie, Paris, France


- 2019: FRM Team Labelisation
- 2015: Winner of the ANR Young Researcher Program
- 2014: Winner of the PSL Structuration d’Equipes start-up grant
- 2006: Prix Jean & Madeleine Schaeverbeke, Fondation de France